Slice the jalapeños lengthwise, then remove the seeds and inner ribs.
Beat the cream cheese until smooth. Mix in cheddar, onion powder, garlic powder, salt, and pepper.
Fill each jalapeño half generously with the cheese mixture.
Wrap each stuffed jalapeño with a bacon slice, ensuring the filling is covered.
Preheat the air fryer to 385°F and lightly grease the basket. Arrange the bites in a single layer and lightly spray with oil.
Air fry for about 20 minutes, shaking every 5 minutes, until the bacon is crisp and golden. Let cool briefly before serving.